Magnesium Orotate

Technical Data Sheets

ITEM
SPECIFICATION
Appearance
White to almost white crystalline powder
Solubility
Practically insoluble in water, 96% ethanol and ether
Identification
A : IR
B: Magneium
shall pass the test
shall pass the test
Specific absorbance by UV spectophotometer
A 1cm (1.0%) 280 – 320
Amino acid test on 1gm sample
Shall be absent
Alkalinity test on 1.5gm of substance suspended in 30ml of water, stir for 5 min and filtered.
10ml of filtrate solution should not consume more than 0.5ml of 0.01N NaoH Solution
Total heavy metals
Not more than 20ppm
Sulphate
Not more than 220ppm
Assay
98% – 101%


Assay for Magnesium Orotate

Weigh accurately about 0.3 g of sample, add 300 ml of water, dissolve by warming and add 10 ml of pH 10.0 ammonia-ammonium chloride buffer solution. Titrate with 0.01 mol/l EDTA until the color of the solution changes from red-purple to blue (indicator: eriochrome black T TS). Perform a blank determination, and make any necessary correction. 1 ml of 0.1 mol/l EDTA = 37.05 mg of Mg Orotate or 2.43 mg of Mg Specific UV absorbance 1% solution in 1 cm cuvette At 285 nm should be 298 – 318 for magnesium orotate

Magnesium orotate:

Magnesium and calcium metabolism are closely related. The intestinal absorption and the renal excretion of the two ions are interdependent. The most frequent causes of hypomagnesemia in children are reduced intake, impaired intestinal absorption, renal loss and genetic diseases. Hypomagnesemia is reflected clinically in the nervous system, and there are neurophysiological and metabolic changes. Severe hypomagnesemia induces secondary hypocalcemia in most experimental animals except rats. Furthermore, severe hypomagnesemia induces functional hypoparathyroidism. In vitro studies have demonstrated that magnesium can modulate parathyroid hormone (PTH) secretion in a similar way to calcium. An acute decrease in magnesium concentration stimulates PTH secretion, and an acute increase in concentration decreases secretion. Magnesium is likely to play an important role in vitamin D metabolism. Some patients with hypocalcemia and magnesium deficiency are resistant to pharmacological doses of vitamin D or may have a form of magnesium-dependent vitamin D-resistant rickets. Phosphate depletion has been observed to be accompanied by an increase in urinary magnesium and calcium. In pediatrics the syndrome of phosphate depletion is observed particularly often in premature babies, who often receive a low-P diet. Magnesium is involved in many of the biochemical reactions that take place in the cell, and particularly in processes involving the formation and utilization of ATP. Thus, at the cellular level, magnesium plays a key role in ionic transport processes.

Magnesium helps in the absorption of calcium in the intestines. It helps convert vitamin D to vitamin D3 (calcitriol0 which absorbs calcium. Magnesium also helps produce calcitonin by thyroid glands which in turn helps to preserve bone structure and draws calcium out of the blood and soft tissues back into the bones, lowering the likelihood of osteoporosis, some forms of arthritis, heart attack and kidney stones

Magnesium orotate is by far the best source of magnesium food supplement. It has the best bioavailability of magnesium besides the bonus of nucleotide buiding characteristics of orotic acid. If bioavailability of magnesium supplement is poor the unabsorbed magnesium may cause side effects such as diarrhoea. Magnesium is an antagonist of calcium and acts as a very friendly calcium blocker acting on the cells.

Magnesium orotate reduces the blood pressure and heart rate of cardiac patients without bad side effects. Since orotic acid is a pyrimidine precursor and is a naturally present chemical in human body it acts as a friendly transporter of magnesium

Magnesium Orotate treats metabolic problems in blood sugar assimilation and hence it mitigates the effect of diabetes and related complications. OROTATES of minerals have been studied in depth by Russian Medical institutes and Magnesium Orotate has been found to be easily the best orotate since it has dual or multiple functions of magnesium therapy along with cardiac , hepatic therapy. In severe congestive heart condition treatments Magnesium Orotate has been proved to be beneficial. Persons treated for mitral valve prolapse and other cardiac dysfunctions recoup better with dosages of magnesium orotate

Magensium Orotate has been in use in the West only for the last few years though its efficacy has been know to the Russians much earlier. It is now well know that magnesium in Magnesium Orotate is more bioavailable than ,say, magnesium citrate etc. Time has come for the medical fraternity to make use of this compound fully. Though it Is costlier than other magnesium supplements, user gets the orotic acid benefits. Harsha Chemicals P.Ltd. is doing its best to make best quality Magnesium Orotate available at very reasonable prices.

CAS: 34717-03-8

MF: C10H6MgN4O8.2H2O

MW: 370.5  252-167-6

Specifcations: Appearance: white / off-white powder Solubility: insoluble in water, methanol etc.

Assay: min 98% (dry basis) – complexometric titration Orotic Acid content – test by colorimetric method. Lead, barium etc : less than 20 ppm

Magnesium Orotate, being a neutral molecule and lipophilic , is easily transported across the cell wall by transporter enzyme.The Orotic Acid moiety is utilized by the OPRTase enzyme for orotidine and uridine synthesis and the magnesium is available for the cells. The OMP which is formed with orotic acid goes on to produce RNA and DNA. UDP which is formed may form UDP-glucose which serves as sugar reservoir and serves the tissues of brain, heart and muscles. The magnesium which is liberated from Magnesium Orotate invigorates the enzymes which breakdown of cholesterol molecule and consequently play a great role in controlling atherosclerosis.